E-Locus - Institutional Repository of the University of Crete

Home Collections Type of Work Post-graduate theses

Post-graduate theses

Search command : Author="Τέρτικας" And Author="Αχιλλέας"

Current Record: 2 of 6616

[Add to Basket]

Identifier

000466060

Title

Development of MCR-based synthetic methodologies via bifunctional starting materials. Applications in lipidoid chemistry

Alternative Title

Ανάπτυξη συνθετικών μεθοδολογιών βασιζόμενες σε χημεία MCR μέσω διλειτουργικών πρώτων υλών. Εφαρμογές στη χημεία λιπιδοειδών

Author

Αναστασίου, Παρασκευή Κλειώ Γ.

Thesis advisor

Νεοχωρίτης, Κωνσταντίνος

Reviewer

Στρατάκης, Μανώλης
Σμόνου, Ιουλία

Abstract

This Master’s thesis is structured into two primary sections, with the principal investigation centered on the synthesis of complex molecules utilizing bifunctional reagents through multicomponent reactions (MCRs). The first section employs a bifunctional reagent bearing both an aldehyde and an acid group in the Ugi four component reaction (U-4CR) and Passerini three component reaction (P-3CR). These reactions result in the interruption of the Mumm rearrangement, initiated by a nucleophile, leading to the formation of substituted derivatives. Consequently, this work proposes two novel interrupted reactions using a bifunctional reagent: the U-5C-4CR and P-4C-3CR. The second section focuses on the synthesis of lipidoids with a polar head, a non-polar segment, and a connecting backbone, aimed at potential drug delivery applications. Four MCRs are employed for this purpose: U-4CR, UT-4CR, P-3CR, and GBB-3CR. In each reaction, a distinct component functions as the polar head and the aliphatic chain, linked via the reaction's backbone.

Language

English

Subject

Lipidoids

Multicomponent reactions (MCRs)

Αντιδράσεις πολλαπλών συστατικών (MCR)

Βifunctional reagents

Διακοπτόμενες αντιδράσεις, λιποειδή

Διλειτουργικές πρώτες ύλες

Ιnterrupted reactions

Λιποειδή

Issue date