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Identifier uch.biology.msc//2004stavride
Title Μεθυλίωση του παράγοντα RFX5, συστατικού του ενισχυοσώματος των γονιδίων τάξης ΙΙ, από τη μεθυλοτρανσφεράση αργινινών CARM1
Creator Stavride, Phivi
Abstract Διατμηματικό, συνεργαζόμενα Τμήματα Βιολογίας και Ιατρικής. A number of post-translational modifications with significance in the MHCII regulation has been reported to date. Most of them belong to the Class II Transactivator, CIITA, the only exception being reports of the RFX complex being phosphorylated, an event whose significance has not been investigated. Here the methylation of RFX5 by the arginine methyltransferase CARM1 (PRMT4) is reported. Both the RFX5 region that binds CARM1 in vitro and the arginine modified have been identified. The methylated arginine is located in the proline-rich region of RFX5 and exhibits sequence similarity with an arginine reported to regulate the interaction of a proline-rich with an SH3 domain. Even more intriguing is the fact that a serine next to the particular arginine is reported to be phosphorylated by PKA, raising the interesting possibility that the two modifications might act in concert.
Issue date 2004-11-01
Date available 2004-12-09
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/d/a/c/metadata-dlib-2004stavride.tkl Bookmark and Share
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