Post-graduate theses
Current Record: 4613 of 6543
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| Identifier |
000375392 |
| Title |
Παρακολούθηση της ανταπόκρισης στη θεραπεία με anti-VEGF ασθενών με αποκόλληση του μελαγχρόου επιθηλίου και ηλικιακή εκφύλιση της ωχράς κηλίδας υγρού τύπου |
| Alternative Title |
The effect of intravitreal injections of anti-VEGF on the pigment epithelial detechment (PED) in eyes with the exudative type of age related macular degeneration (AMD) |
| Creator |
Καλουδά, Πελαγία Γ
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Thesis advisor
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Τσιλιμπάρης, Μιλτιάδης
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Reviewer
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Κυμιωνής, Γεώργιος
Σιγανός, Χαράλαμπος
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| Abstract |
PURPOSE:
The aim of this retrospective study is to evaluate the morphological changes of the
extent of the PED with optical coherence tomography (OCT), after treatment with
intravitreal injections of anti-VEGF in eyes with the exudative type of AMD. It will
also be determined whether there is any correlation between morphological
alterations of the PED and improvement in visual acuity. Furthermore, visual acuity
and number of injections will be compared in pairs to a control group.
METHODS:
In this retrospective chart review of patients with PED and exudative type of AMD
treated with intravitreal injections of anti-VEGF, data were collected at the fundus
Ophthalmology department of University Hospital of Heraklion, Crete. There was
also a control group, matched in pairs to the PED group, with the same
characteristics (AMD treated with anti-VEGF) with no PED component on the OCT
examination. 30 eyes were included in each group (totally 60 eyes of 58 patients).
Mean age of the PED group was 75.7 years (± 5.8 years), while the control group’s
was 77.7 years (±6.2 years). Mean follow up period was 19.8 months (±10.7 months).
Alterations of the extent of the PED were defined by three independent investigators
as: unchanged- if it appeared qualitatively similar to the baseline exam at the end of
the follow up, reduced- if it appeared qualitatively smaller, significantly reduced- if
no PED could be detected and increased- if it appeared qualitatively larger.
Moreover, visual acuity and number of injections were recorded from patients’ files.
RESULTS:
Changes of the PED morphology were found as follows: unchanged 11 eyes (36.7%),
reduced 12 eyes (40%), significantly reduced 7 eyes (23.3%), increased 0 eyes (0%).
Correlation between morphological alterations of the PED and improvement in visual
acuity of the PED group was not statistically significant (p=0.712).
Initially, the mean best corrected visual acuity (BCVA) of both the 2 groups was 0.47
logMAR (±0.26logMAR). At the end of the follow up, mean BCVA of the PED group
was 0.45 logMAR (±0.47logMAR), whereas the control group’s was 0.53 logMAR
(±0.42logMAR). The mean paired difference in BCVA comparing the two groups was
-0.08 logMAR (p=0.46).
Furthermore, the mean paired difference in the number of injections was 2.1
injections (p=0.04).
CONCLUSION:
After treatment with intravitreal injections of anti-VEGF in eyes with the exudative
type of AMD and PED, a substantial number of the studied patients showed
reduction/significant reduction of the extent of the PED. However, this improvement
does not correlate to better visual acuity. Comparing in pairs to a control group with
AMD treated with anti-VEGF but with no PED component, there were no statistically
significant differences in visual acuity. However, it was statistically significant that
the PED group required a greater number of injections compared to the control
group.
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| Language |
Greek |
| Subject |
Eye Diseases |
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Retinal Detachment |
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Αμφιβληστροειδούς αποκόλληση |
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Οφθαλμικά νοσήματα |
| Issue date |
2011-12-15 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/d/b/2/metadata-dlib-1347604801-266800-5550.tkl
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| Views |
230 |
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