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Identifier

000434003

Title

Classification of genomic properties of eukaryotic genes against three-dimensional A/B compartments

Alternative Title

Διαμερισματοποίηση γονιδιωματικών ιδιοτήτων σε επίπεδο γονιδιωματικών Α/Β διαμερισμάτων

Author

Λιανουδάκη, Ελένη

Thesis advisor

Νικολάου, Χριστόφορος

Reviewer

Παυλίδης, Παύλος
Ηλιόπουλος, Ιωάννης

Abstract

The particular thesis constitutes a thorough examination and classification of the genomic properties of A/B compartments in eukaryotic genes and particularly in human genes. The main goal was to identify differences on the way genes are distributed in the compartments. Those differences elaborated mainly on the size of the genes, the complexity of the genes (number of exons/introns, number of alternative transcripts, GC content etc), conservation of genes on those regions, chromosomal characteristics (nucleosome positioning) and variation of compartments coordinates in different cell types. Consequently, the genes and transcripts included in each of the six subcompartments that A/B compartments are divided (Rao et al., 2014) were identified and analyzed. Then, in accordance with the findings an association of clusters of genes or transcripts, having specific properties concerning the aforementioned features, with particular subcompartments was attempted. The final objective was to unveil undiscovered features of those regions and try to correlate gene functions with structure. These associations could end up being indicative of a possible compartmentalization of the three dimensional organization of the nucleus.

Language

English

Subject

Chromatin

Compartmentalization

Οργάνωση χρωματίνης

Issue date

2020-12-17

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses

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