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Identifier 000436386
Title Induction of immunogenic cell death during anticancer therapy. : Clinical applications and challenges
Alternative Title Επαγωγή ανοσογόνου κυτταρικού θανάτου κατά την αντικαρκινική θεραπεία
Author Πρεβεζάνου, Μαρία
Thesis advisor Πλέτσα, Βασιλική
Reviewer Τσιτσιλώνη, Ουρανία
Τρουγκάκος, Ιωάννης
Abstract Effective killing of cancer cells is the main goal of cancer treatment. Avoiding cell death is one of the characteristics of cancer cells that often show resistance. Therefore, the investigation of the mechanisms of cell death induced during anticancer treatment has been a cutting-edge issue for about a decade because it significantly determines the effectiveness of anticancer agents. In the design of effective anti-cancer immunotherapies that lead to the undoing of the phenomenon of anti-cancer immunity, it is necessary to exploit the immunogenic potential of cancer cells that die or are already dead. The cellular death observed under these conditions is often associated with the activation of risk signaling pathways and the release of molecular patterns related to lesions (Damage-associated molecular patterns: DAMPs). This mechanism called Immunogenic Cell Death (ICD) significantly increases the immunogenicity of dying cancer cells, occurs through programmed cell death (Apoptosis and/or Necroptosis) and is induced in vitro and in vivo by many chemotherapeutic agents. This work will present recent developments in the field and comment on the challenges that need to be met in the near future, with an emphasis on linking ICD with immunotherapy and its use in combined cancer treatments in the clinical practice.
Language English
Subject Ανοσογόνος κυτταρικός θάνατος
Issue date 2020-12-17
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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