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Identifier 000434804
Title Maternal diet may modify associations of prenatal air pollution with allergy and lung function in the offspring
Alternative Title Η διατροφή της μητέρας ενδέχεται να τροποποιήσει την συσχέτιση της έκθεσης ,κατα την εγκυμοσύνη ,στην ατμοσφαιρική ρύπανση με την εμφάνιση αλλεργιών και πνευμονική λειτουργία του νεογνού
Author Αθανασάκη, Ελένη
Author Αθανασάκη, Ελένη
Thesis advisor Λιονής, Χρήστος
Βαφειάδη Μαρίνα
Ιεροδιακόνου, Δέσπω
Abstract Introduction: Maternal exposure to air pollution during pregnancy is associated with the occurrence of allergies and lung malfunction. Studies result that maternal exposure may affect the outcome and that maternal adherence to Mediterranean diet during pregnancy has a protective role against PM effect. To date no studies asses the possible protective effect of maternal Mediterranean diet with PM exposure and the possibility of allergies and lower lung function in the offspring during childhood. Hypothesis: If maternal adherence to Mediterranean diet during gestation, may modify the outcome of allergy (eczema, allergic rhinitis, asthma) and lung function in the offspring, during childhood when there is PM exposure during pregnancy. Aim: The aim of the present study was to investigate the associations of prenatal exposure to air pollution with allergy-related outcomes in childhood, and to assess whether maternal adherence to Mediterranean diet during pregnancy modifies these associations. Methods: Measurements were taken on 744 children at the age of 4 and on 540 at the age of 6 whose mothers are participating in the Rhea mother-child cohort study. Results: PM2.5 exposure is associated with eczema and allergic rhinitis occurrence, but not with the occurrence of asthma or with lung function. Effect modification by Mediterranean diet showed a protective role against the occurrence of eczema, allergic rhinitis and asthma in specific time points of pregnancy and age of children. PM10 exposure is associated with the occurrence of eczema, allergic rhinitis, but not with asthma and lung function. Effect modification by Mediterranean diet showed a protective role against eczema and allergic rhinitis, but not asthma and lung function. Conclusion: The findings suggest interplay between prenatal PM exposure adherence to MD on the development of allergies (eczema, rhinitis and asthma) and lung function in the offspring during childhood. The data presented could support dietary interventions during gestation for mitigating offspring risk of allergies against prenatal exposure to air pollution.
Language English
Subject Allergic Rhinitis
Asthma lung function
Eczema
Mediterranean diet
Issue date 2020-12-17
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/b/6/c/metadata-dlib-1607689769-959281-29307.tkl Bookmark and Share
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