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Identifier 000441444
Title Συστηματική ανασκόπηση της παγκόσμιας εποχικότητας σε λοιμώξεις από Ψευδομονάδα που σχετίζονται με την υγειονομική περίθαλψη.
Alternative Title A systematic review of the global seasonality in healthcare-associated infections caused by Pseudomonas species.
Author Κωστοπούλου, Μαρία
Thesis advisor Κριτσωτάκης, Ευάγγελος
Reviewer Γκίκας, Αχιλλέας
Abstract Background: Pseudomonas is an opportunistic pathogen that causes serious infections, especially in healthcare facilities. It displays great capability in microbial resistance spread and it is considered an important threat concerning the global morbidity and mortality. Higher incidence rates of Pseudomonas infections been reported during summer months, albeit no systematic retrieval and synthesis of either seasonal patterns or factors potentially leading to seasonality exist. Objectives: To systematically collate and examine the evidence describing global seasonal patterns in the incidence of Pseudomonas infection in hospitalized patients. Data sources: Medline/Pubmed, Google Scholar, Scopus. Study eligibility criteria: Longitudinal observational studies investigating seasonal variation in the incidence of Pseudomonas infection. Participants: Patients receiving hospital care. Methods: Systematic review with structured synthesis around clinical and methodological heterogeneity and internal validity of retrieved studies, seasonal patterns and risk factors detected, and stated hypotheses of mechanisms underlying seasonality. To examine seasonal patterns across different conditions, monthly incidence data were extracted, standardised, weighted and presented graphically. Results: Twenty-nine studies reporting 52373 cases of Pseudomonas infection or colonization during 2192 months of follow-up. Standardised monthly incidence data pooled across studies exhibited a global seasonal pattern with an incidence peak in warmer months (summer) and a trough in colder months (winter). This seasonal pattern remained consistent under different weighting schemes. Conclusions: In the present systematic review, a consistent global seasonal pattern in Pseudomonas infection incidence in hospitalized patients was evident, despite substantial clinical and methodological heterogeneity in retrieved studies. This finding could be taken into account during designing or evaluating infection control interventions in hospitals. Also, future research should focus on elucidating driving mechanisms underlying the observed seasonality.
Language Greek
Subject Epidemiology
Λοιμώξεις που σχετίζονται με νοσοκομειακή περίθαλψη
Issue date 2021-07-29
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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