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Identifier 000442408
Title Population demographic models and PCA analysis : translating a PCA graph into population parameters. / Aspasia Orfanou ; supervisors Pavlos Pavlidis,Fotis Psomopoulos,Tereza Manousaki.
Alternative Title Πληθυσμιακά δημογραφικά μοντέλα και PCA
Author Ορφανού, Ασπασία
Thesis advisor Παυλίδης, Παύλος
Reviewer Ψωμόπουλος, Φώτης
Μανουσάκη, Τερέζα
Abstract Due to the rapid growth of genetic data and the fact that inferring population relationships from genome data seems challenging, principal component analysis known as PCA is a commonly used method to detect and interpret the genetic structure of populations along with possible associations between them. In this paper we aim to show that using SNP data produced with msprime algorithm , PCA succeeds more often to locate correlation of populations than Fst, t-SNE and a couple of other methods. In addition, the goal of this study was to find under which conditions PCA becomes weak and suggest an alternative method for better recognition of population relationships.
Language English
Issue date 2021-12-01
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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