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Identifier 000446153
Title Τοπικά αναισθητικά μέσω αντιδράσεων πολλών συστατικών
Alternative Title Local anesthetics via multicomponent reactions
Author Θωμαΐδη, Μαρία Θ.
Thesis advisor Νεοχωρίτης, Κωνσταντίνος
Reviewer Βασιλικογιαννάκης, Γεώργιος
Σιδηροπούλου, Κυριακή
Abstract Humanity has always been confronted with the sensation of pain, with anesthesia (general or local) being vital, forming the cornerstone for treating this sensation in surgeries and not only. Until now, the synthesis of the already known local anesthetics (LA) is carried out through several steps that require time, cost and effort, while at the same time it is necessary to find new local anesthetics with improved properties. Additionally, a big class of LA can be synthesized via the Ugi reaction (U3CR). Thus, in the present master thesis, an improved synthesis was performed of not only known and commercially available LAs, but new ones with different and diverse scaffolds in one step via multicomponent reactions-MCRs. Compounds related to the broader canal diseases were also synthesized. Next, the activity of certain derivatives synthesized as effective Na+ pump inhibitors in isolated slices of the hippocampal region of mice was studied.
Language Greek
Subject Aminoamides
Na+ pump inhibitors
Ugi reaction
Αμινοαμιδικές ενώσεις
Αναστολείς αντλίας Na+
Αντίδραση Ugi
Issue date 2022-03-31
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
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