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Identifier 000431822
Title Η χρησιμότητα του λεμφαδένα φρουρού ως αντικατάσταση της συστηματικής πυελικής λεμφαδενεκτομής στον καρκίνο του ενδομητρίου
Alternative Title Sentinel lymph node as an alternative to systematic lymphadenectomy in endometrial cancer staging
Author Τιμοθέου Σταύρος Α.
Thesis advisor Βρεκούσης, Θωμάς
Reviewer Αγγελάκη, Σοφία
Λασιθιωτάκης, Κωνσταντίνος
Abstract Objective: To compare sentinel lymph node mapping accuracy (detection rates, sensitivity, negative predictive values) versus the gold standard of systematic lymphadenectomy (pelvic with or without paraortic) Methods: We conducted a Pubmed search on every study published in English. Inclusion criteria were studies with sample sizes 20 or more women with endometrial cancer having undergone sentinel lymph node mapping. Only studies comparing sentinel lymph node mapping to systematic lymphadenectomy and reported on all parameters of accuracy included in the results. Data was analysed using descriptive statistics. Results: We identified 36 eligible studies, 19 used a single technique, 11 used different double combinations, 1 triple combination, one used random combination and four used alternatively different techniques. Indocyanine green appear to have better sensitivity and negative predictive value comparing to blue dyes or Tc99m and more convenient to Tc99m. In regard to blue dyes, methylene blue is performing better. Combination of techniques also demonstrate high detection rates, sensitivity and negative predictive value. No definite conclusion can be made on the best injection site due to scarcity of studies exploring other than the cervix sites. Conclusion: Sentinel lymph node mapping may be considered an accurate alternative to lymphadenectomy in endometrial cancer staging. However, more studies needed to explore different techniques and injection sites such as sub serosal or sub endometrial. Study focus on the safety of sentinel lymph node mapping in endometrial cancer is necessary.
Language Greek, English
Subject Λεμφαδένας φρουρός
Issue date 2020-08-05
Collection   Faculty/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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