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Identifier 000429742
Title Εffect of nerve growth factor and synthetic neurosteroids on the phenotype of adipocytes
Alternative Title Επίδραση του αυξητικού παράγοντα των νεύρων και συνθετικών νευροστεροειδών στο φαινότυπο των λιποκυττάρων
Author Δεικτάκης, Μιχαήλ
Thesis advisor Δερμιτζάκη, Ειρήνη
Reviewer Βενυχάκη, Μαρία
Χαραλαμπόπουλος, Ιωάννης
Μαργιωρής, Ανδρέας
Abstract The adipose tissue is mainly responsible for energy homeostasis and secretes a variety of factors. Energy is stored by adipocytes in the form of lipids which are used in the event of energy demand. When caloric intake is greater than expenditure, adipocytes tend to become hypertrophic, which poses the threat of obesity and its co-morbidities. Cold exposure and exercise are some major positive regulators of metabolic function, contributing to the browning of white adipose tissue. Both the fact that neurotrophin receptors reside in the adipose tissue and the need for the development of a metabolically beneficial drug led us to test the effect of nerve growth factor (NGF) and a synthetic microneurotrophin devoid of steroid actions, BNN27, on the adipocyte function. Human white mature adipocytes and pre-adipocytes were isolated from tissue samples offered by volunteers undergoing surgery. In addition, when the aforementioned were not available, the 3T3L1 pre-adipocyte cell line was used. NGF increased mitochondrial respiration and glycolysis in 3T3L1 pre-adipocytes and reduced mitochondrial mass, ROS production and the number of intracellular lipids in human mature adipocytes whereas, BNN27 increased metabolic functions but had not any significant effect on the adipocyte lipids content. Overall, the above results indicate that these molecules may have a possible role on the regulation of the metabolic profile of adipocytes.
Language Greek
Subject Metabolic function
Αυξητικός παράγοντας των νεύρων
Μεταβολική λειτουργία
Φλεγμονώδης φαινότυπος
Issue date 2020-08-05
Collection   Faculty/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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