Post-graduate theses

Search command : =""

Current Record: 4 of 6532

[Add to Basket]
Identifier	000463213
Title	Development of a computational male pelvis phantom for the generation of multiseries MRI synthetic data in support of image analytic processes
Alternative Title	Ανάπτυξη ενός υπολογιστικού Phantom αρσενικής πυέλου για την δημιουργία συνθετικών δεδομέμων απο πολλαπλές σειρές MRI για την υποστήριξητεχνικών ανάλυσης ιατρικών εικόνων
Author	Γιουρούκου, Κωνσταντίνα
Thesis advisor	Μαριάς, Κωνσταντίνος
Reviewer	Νικηφοράκη, Αικατερίνη Μανίκης, Γεώργιος
Abstract	In this thesis, we utilize existing tools to simulate a data acquisition process and extend their capabilities to a virtual phantom with human anatomy characteristics. Our proposed method involves the creation of a computational male pelvic phantom and the utilization of advanced software to simulate magnetic resonance imaging (MRI) processes, by solving Bloch equations. This work has the potential for important future applications regarding the address of standardization challenges in radiomics, contributing to explainability, robustness, and repeatability in the extraction of radiomic features. To accurately represent pelvis anatomy, we employed clinical MRI images, leveraging the benefits of tomography and advanced medical image processing techniques. Specifically, we employed segmentation and labeling methods to delineate and differentiate each tissue, faithfully reproducing the spatial distribution of muscles and fat—the primary components constituting the pelvis. In MRI, each tissue exhibits distinct parameters such as T1, T2, T2*, and proton density, which are related to the signal and the intrinsic contrast of each tissue. In this study, we assigned tissue properties that relied on established values from the literature. For simulation purposes, we utilized the specialized MRI simulator software, MRiLab. The implementation of the fundamental clinical sequence, Spin Echo (SE), coupled with the investigation of three distinct contrasts (T1-weighted, T2-weighted, and proton density-weighted), forms a well-examined study. In our experimental results, we showcase the MRI images generated through the simulation of the male pelvic phantom and highlight specific applications in image analysis. The methodology employed for phantom creation can be extended for deployment in any body region, allowing the digital reproduction of patient-specific or requested anatomical structures for various research studies. Leveraging the MRI simulator facilitates the application of clinical MRI protocols and the generation of necessary image data-sets. The potential applications and versatility of our phantom are extensive, spanning from computational measurements and physics estimations to the generation of synthetic data for training artificial intelligence models. Furthermore, its utility extends to preclinical trials and educational purposes. In conclusion, our phantom could be valuable in radiomic analysis. Its application emerges as a potential solution to standardization challenges in radiomic features and facilitates a comprehensive examination of variability issues across various clinical protocols.
Language	English
Subject	Customizeddigital MRI Phantom
	Image processing and analysis
	MRI simulation
	Δημιουργία ψηφιακών MRI Phantom
	Επεξεργασία και ανάλυση Ιατρικών εικόνων
	Προσωμοίωση μαγνητικής τομογραφίας
Issue date	2024-04-17
Collection	School/Department--School of Medicine--Department of Medicine--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/4/7/d/metadata-dlib-1712917687-627505-1286.tkl
Views	2

Digital Documents
	Download document View document Views : 0