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Identifier 000452849
Title 4D printing of bioscaffolds for bone tissue engineering.
Author Λαμπράκης, Αλκαίος
Thesis advisor Στρατάκης, Εμμανουήλ
Reviewer Μπάλας, Κωνσταντίνος
Ρανέλλα Ανθή
Abstract Bone tissue engineering is an interdisciplinary biomedical field that has gained a lot of interest the last years due to many technological breakthroughs. The use of fused deposition modelling and 3d/3D printers enables the creation of complex 3d scaffolds with the help of computer assisted design. The addition of a laser source enhances the resolution of the designs by adding a very precise subtractive tool to the equation, while also adding a fourth dimension to the printed material. The resolution a 3d printer can achieve is at best about 0.1 mm. The addition of the laser source allows to reach resolutions more than ten times higher, about 0.01 mm or less, depending on the laser source. The scaffolds are mainly made from thermoplastic polymers and polylactic acid is the gold standard, due to its printing and bio-friendly properties. Using natural PLA filament in a commercial 3d printer and nanosecond pulses from a fiber laser source, we created 4d PLA scaffolds with pore size down to 50 microns, by laser ablation. Other materials used to produce 3D and 4D scaffolds were the PCL and PCL with 10% Cellulose acetate. SEM and confocal characterization showed enhanced adhesion and proliferation of various cell cultures to the 4d scaffolds, when compared to control, while the mechanotransduction profile obtained was due to the material stiffness and cellular morphology. Such printed scaffolds with controlled micro and macro-porosities could be an advanced and safer approach for treating tissue defects eg. bone. Our results indicate a promising technique that can further be used to create scaffolds by creating more complex CADs. This Thesis has been performed at the Ultrafast Laser Micro and Nano Processing Laboratory of IESL-FORTH.
Language English, Greek
Subject Bone
Scaffolds
Ικριώματα
Μηχανική ιστών
Οστό
Issue date 2022-12-07
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/e/d/d/metadata-dlib-1671184265-576207-8571.tkl Bookmark and Share
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