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Identifier 000435042
Title ‘Exploring molecular mechanisms of interaction of filamentous fungi with neutrophils
Alternative Title Ανάλυση μοριακών μηχανισμών αλληλεπίδρασης υφομυκήτων με ουδετερόφιλα
Author Μπάιμπα, Σταυρούλα
Thesis advisor Χαμηλός, Γεώργιος
Abstract Fungal Kingdom includes about 6 million species, however only a few hundred are associated with human diseases. Mucormycosis is a rare-yet an emerging invasive fungal disease caused by fungi of the Mucorales order, characterized with high mortality rates of almost 100% in the case of disseminated infection. Neutrophils are essential players of the host innate immunity against filamentous fungi. Although one of the major risks factors of Mucormycosis is neutropenia, the molecular mechanisms of neutrophil interaction with Mucorales remain unknown. In this project, our aim was to establish ex vivo imaging and killing assays to investigate the interaction between murine and human neutrophils and the main causative agent of Mucormycosis, Rhizopus oryzae In contrast to the other major aerial fungal pathogen Aspergillus fumigatus, we found that neutrophils do not phagocytose Mucorales conidia but instead selectively form clusters surrounding them, a phenomenon recently described as neutrophil swarming. Importantly, swarming was not observed against Aspergillus conidia. Pilot studies suggest that fungal cell wall melanin of Rhizopus conidia likely account for induction of swarming. Furthermore, we found that neutrophils inhibit R. oryzae conidia germination. Further experiments should clarify host and fungal molecular elements regulating this immune response against Mucorales and elucidate the role of swarming in disease pathogenesis
Language English
Subject Fungi
Innate immunity
Rhizopus oryzae
Έμφυτη ανοσία
Issue date 2020-12-17
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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