Post-graduate theses

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Identifier	000369795
Title	Η σηματοδότηση Notch μέσω ενδοκύττωσης, η περίπτωση της πρωτεϊνης Delta
Alternative Title	Notch Signalling via endocytosis - the case of Delta
Author	Τσουμπέκος, Γεώργιος
Thesis advisor	Δελιδάκης, Χρήστος
Abstract	The Notch transmembrane receptors are activated by transmembrane ligands of the DSL family, which is subdivided into the Delta and Serrate / Jagged subfamilies in higher metazoans. Even when Notch and DSL are engaged in trans, signaling ensues only when DSL proteins are activated by an ubiquitin E3 ligase. Work from our lab and others over the past decade has characterized two families of RING domain E3 ligases which have the ability to activate DSL proteins, Neuralized and Mindbomb1. Ubiquitylation of plasma membrane proteins is a signal for endocytosis, as well as further sorting steps in intracellular trafficking. Here we have molecularly dissected the Drosophila Dl ICD and have tested two parameters: (Ι) subcellular distribution of Dl, (ΙΙ) ubiquitylation by different E3 ligases, only in Dlwt. In order to achieve aim (ΙΙ), we tested new membrane associated Ub ligases to determine whether they might use Dl as a substrate: Cbl-S (S: short isoform of Cbl protein) and Dx.
Language	Greek
Subject	E3 Ligases
	Oybiquitinylation
	Ε3 Λιγασες
	Ουβικουϊτινυλίωση
Issue date	2011-11-18
Collection	School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/d/a/6/metadata-dlib-1321615181-441478-4621.tkl
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