Post-graduate theses
Current Record: 4608 of 6695
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Identifier |
uch.biology.msc//2004stavride |
Title |
Μεθυλίωση του παράγοντα RFX5, συστατικού του ενισχυοσώματος των γονιδίων τάξης ΙΙ, από τη μεθυλοτρανσφεράση αργινινών CARM1 |
Creator |
Stavride, Phivi
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Abstract |
Διατμηματικό, συνεργαζόμενα Τμήματα Βιολογίας και Ιατρικής. A number of post-translational modifications with significance in the MHCII regulation has been reported to date. Most of them belong to the Class II Transactivator, CIITA, the only exception being reports of the RFX complex being phosphorylated, an event whose significance has not been investigated. Here the methylation of RFX5 by the arginine methyltransferase CARM1 (PRMT4) is reported. Both the RFX5 region that binds CARM1 in vitro and the arginine modified have been identified. The methylated arginine is located in the proline-rich region of RFX5 and exhibits sequence similarity with an arginine reported to regulate the interaction of a proline-rich with an SH3 domain. Even more intriguing is the fact that a serine next to the particular arginine is reported to be phosphorylated by PKA, raising the interesting possibility that the two modifications might act in concert.
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Issue date |
2004-11-01 |
Date available |
2004-12-09 |
Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/d/a/c/metadata-dlib-2004stavride.tkl
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Views |
265 |