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Identifier

000388564

Title

Το μονοπάτι στόχευσης της υπομονάδας e (subunit e/Tim11) της μιτοχονδριακής ATP συνθάσης στην εσωτερική μεμβράνη των μιτοχονδρίων του σακχαρομύκητα S. cerevisiae

Alternative Title

The import pathway of subunit e/Tim11 of the mitochondrial ATP synthase in the inner membrane of yeast mitochondria

Author

Χαραλάμπους, Γεωργία Χ.

Thesis advisor

Τοκατλίδης, Κ.

Abstract

Mitochondria are very important organelles for the cells as they perform procedures that are necessary for life. One of them is oxidative phosphorylation (OXPHOS), in which four complexes of electron transport chain and F1-F0 ATP synthase take part. F1-F0 ATP synthase is the enzyme that catalyzes the final step of the procedure, the production of the energy molecule ATP. This enzyme is found in dimeric/oligomeric forms in mitochondria. Especially in yeast Saccharomyces cerevisiae, the enzyme consists of 17 well-characterized subunits, some encoded by mitochondrial DNA in the matrix of mitochondria and others encoded by the nucleus. Those encoded by the nucleus are imported in the organelles via specific sorting pathways leading the proteins to the mitochondrial subcompartments. Subunit e (Tim11) is encoded by the nucleus and is found anchored in the inner membrane of mitochondria. It is considered as an important subunit responsible for the dimerization of the ATPase and for the cristae formation inside mitochondria. Tim11’s aminoacid sequence doesn’t seem to have a known peptide signal which leads precursor proteins to the inner membrane of mitochondria and thus the study of Tim11’s import and association with the inner membrane was considered to perhaps enrich the database of peptide signals or even lead to the identification of a new import pathway to the inner membrane.

Language

Greek

Subject

Membrane potential

Oxidative stress

Tim11/Sue

Μεμβρανικό δυναμικό

Μιτοχόνδρια

Οξειδωτικό στρες

Issue date

2014-11-21

Collection