Your browser does not support JavaScript!

Home    Collections    Type of Work    Post-graduate theses  

Post-graduate theses

Current Record: 6 of 5394

Back to Results Previous page
Next page
Add to Basket
[Add to Basket]
Identifier 000441048
Title Astrocyte-mediated effect of hyperglycemia on mouse neural stem cells
Alternative Title Η επίδραση της υπεργλυκαιμίας στα νευρικά βλαστικά κύτταρα μέσω των αστροκυττάρων
Author Καραμούστου, Ελευθερία
Thesis advisor Χαραλαμπόπουλος, Ιωάννης
Abstract Diabetes and hyperglycemia are well-known for inducing deleterious effects on physiological processes and are associated with several pathological conditions such as cardiovascular diseases, peripheral neuropathy, retinopathy, and nephropathy. The impact of metabolic disorders such as diabetes and obesity on the central nervous system (CNS) has been widely studied. In specific, diabetes impairs brain morphology and function and especially normal adult neurogenesis in the hippocampus. Therefore, diabetes is strongly associated with a higher risk to develop Alzheimer’s disease (AD) as the hippocampus is among the first brain structures to be affected by AD pathology. However, diabetes does not only have an effect on neurons and neural stem cells but also on glial cells. Astrocyte-neuron interactions are involved in the pathogenesis of several neurologic diseases while molecules secreted by astrocytes can affect adult neural stem/progenitor cells and can increase their differentiation into neurons. High glucose exposure has been also shown to alter astrocytes function and to increase the expression of inflammatory cytokines. Inflammation and apoptosis in the brain have been associated with the p75 neurotrophin receptor (p75NTR). Moreover, the p75 neurotrophin receptor is involved in a variety of other cellular responses, as it is capable of mediating cell survival and neuronal differentiation. p75NTR can also regulate specific aspects of neurogenesis while it is also expressed by glial cells and oligodendrocytes. In this context, our study focused on the effect of hyperglycemia on neural stem cells (NSCs) and astrocytes properties as well as on the astrocyte-mediated effect of hyperglycemia on NSCs. It was shown that hyperglycemia impairs different aspects of neurogenesis as well as it induces astrocytes reactivity. High glucose exposure not only affects directly the NSCs but it can also affect neurogenesis via astrocytes. P75NTR activation may contribute to hyperglycemia-mediated alterations in stemness, proliferation and apoptosis of NSCs as well in astrocyte response to high glucose exposure.
Language English
Issue date 2021-07-30
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link Bookmark and Share
Views 4

Digital Documents
No preview available

Download document
View document
Views : 1