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Identifier 000435036
Title Exploring molecular mechanisms of antifungal activity of human serum
Alternative Title Εξερεύνηση των μοριακών μηχανισμών της καταπολέμησης μυκήτων από τον ανθρώπινο ορό 2020
Author Νίδρης, Βασίλειος
Thesis advisor Χαμηλός, Γεώργιος
Πίκουλας, Α.
Abstract Fungi are saprophytic organisms, which rarely cause infections in humans. However, immunocompromised patients can be affected by invasive diseases caused by filamentous fungi (molds), mainly Aspergillus spp. and the Mucorales. Mucormycosis is a devastating disease with high mortality rates that can exceed 80% in disseminated disease. When compared to other fungal diseases mucormycosis has unique epidemiological and pathogenetic features. Metabolic abnormalities, including poorly controlled diabetes mellitus, acidosis, and iron overload syndromes, are unique risk factor for Mucormycosis development. Immunosuppression associated with treatment of hematologic malignancies and transplantation is also a major risk factor for Mucormycosis. Inhibition of intracellular and extracellular fungal growth is an essential host defense strategy against Mucorales. It has been shown that human serum can inhibit the growth of fungi spores via incompletely understood mechanisms. Unpublished data have demonstrate that low serum albumin levels are associated with development of Mucormycosis. In our work we explored whether albumin has direct antifungal activity against Mucorales spores. Herein, we found that free fatty acids bound to albumin inhibit germination of Mucorales spores, block the expression of major virulence factors and attenuate fungal pathogenicity in vivo. Our findings reveal a previously uncharacterized immunological function of albumin with potential therapeutic implications in management of mucormycosis.
Language English
Subject Albumin
Inate immune response
Rhizopous oryzae
Ενδογενής ανοσία
Issue date 2020-12-17
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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