Your browser does not support JavaScript!

Home    Collections    Type of Work    Post-graduate theses  

Post-graduate theses

Current Record: 9 of 6461

Back to Results Previous page
Next page
Add to Basket
[Add to Basket]
Identifier 000460760
Title Developing a system to study multimodal association of stimuli in mice
Alternative Title Ανάπτυξη συστήματος για τη μελέτη πολυτροπικής συσχέτισης ερεθισμάτων στο ζωικό μοντέλο των μυών
Author Βαρβούτη, Δήμητρα
Thesis advisor Φρουδαράκης, Εμμανουήλ
Reviewer Ποϊράζη, Παναγιώτα
Παπουτσή, Αθανασία
Abstract Associating various sensory information to visual objects is a fundamental cognitive process that enhances the ability to recognize objects and improves memory performance. Mice are capable of invariant object recognition in their natural environment , however the associated changes of object manifolds along the cortex remain widely unknown. We suggest a new approach by establishing multimodal association of stimuli to determine if there is an overlap between neuronal populations who respond to different properties of the same object. Specificall y, the question we are trying to address is whether the manifold of an object is formed in V1 area, while the mouse is exposed to an associated odor, giving us a chance to better identify which subgroup of neurons are actually responsible for object recognition. Using home cage training, we examined the ability of two different strains of mice ( C57BL/6 J & Thy1 GCaMP6 ) to associate a visual object with an odor. We found differences between strains during the behavioral training while propos ing three different experimental paradigms (Go/ 2AFC , M2S in order to conclude which is the most suitable. Furthermore, we finely tuned several different parameters that play a significant role in automated behavioral training. Overall, it was challenging to establish such an association while ensuring that the animals consider both stimuli to make decisions.
Language English
Subject Mental imagery
Object recognition
Promary visual cortex
Αναγνώριση αντικειμένου
Πολυτροπικός
Πρωτογενής οπτικός φλοιός
Issue date 2023-12-08
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/a/2/6/metadata-dlib-1701342049-216915-16259.tkl Bookmark and Share
Views 1091

Digital Documents
No preview available

Download document
View document
Views : 0