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Identifier 000444172
Title Evolution of conserved non-coding elements in teleost fish
Alternative Title Εξέλιξη των συντηρημένων μη κωδικών στοιχείων στους τελεοστέους
Author Ηλιοπούλου, Ελισάβετ
Thesis advisor Ηλιόπουλος, Ιωάννης
Reviewer Παυλίδης, Παύλος
Μανουσάκη, Τερέζα
Abstract Many genes associated with evolutionarily conserved functions are proximal to highly Conserved Non-coding Elements (CNE), which often act as enhancers of their neighboring genes. A small number of studies have suggested loss and rapid evolutionary divergence of CNE in teleost fish. Here, we focused on identifying and studying the teleost CNE repertoire, taking advantage of the recent increase in high-quality genomes. We developed a comparative genomics pipeline to align genomes and detect CNEs. Moreover, we built CNE-based phylogenomic trees, to test their potential in resolving teleost phylogenetic placements and study CNE loss, gain and evolutionary divergence across teleosts. Finally, we attempted to gain information on the potential of identified CNE as developmental enhancers, by associating them with proximal developmental genes. This study provided insight on CNE evolution in teleost fish and a set of putative conserved developmental cis-regulatory elements that show promise for further experimental testing.
Language English
Subject Enhancers
Pairwise whole genome alignment
Phylogenomic analysis
Ολόκληρος διπλασιασμός του γονιδιώματος
Συντηρημένα μη κωδικά στοιχεία
Φυλογενωμική ανάλυση
Issue date 2021-12-01
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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