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Identifier 000431659
Title LncRNAs: ρύθμιση, λειτουργία και καρκίνος : Ανασκόπηση της διεθνούς βιβλιογραφίας
Alternative Title LncRNAs: regulation ,function and cancer
Author Δρύλλης, Γεώργιος Ι.
Thesis advisor Ζουμπουρλής, Βασίλειος
Reviewer Σουρβίνος, Γεώργιος
Αγγελάκη, Σοφία
Abstract Numerous studies have documented that lncRNA plays a key role in tumorigenesis and tumor progression. In particular, abnormal lncRNA expression may accompany DNA damage, immune escape as well as cellular metabolic disorders in cancer cells. The di versity and heterogeneity of lncRNAs make the complicated tumorigenesis process even more intriguing. In addition, lncRNA is also strongly associated with EMT, as well as the regulation of cell stemness. These findings together make lncRNA a solid compone nt of tumor metastasis. Therefore, targeting lncRNA could be an opportune clinical approach in cancer treatment. Combination therapy has made great progress in the clinical treatment of tumors. Combining surgery with chemotherapy, or the emergence of spec ific targeted drugs, has further improved the survival rate of patients. Recently, with the significant clinical achievements in immunotherapy of PD1/PD L1, ideas focusing on the re stimulation of the suppressed cellular immunity of patients through immuno therapy have been under the limelight of cancer research. As a part of the immune escape of cancer cells, lncRNAs may provide new insight for future cancer treatment combined with immunotherapy. The rapid development of a new generation of gene editing tools makes it possible to target lncRNA inside tumor cells. ASOs or CRISPR/ Cas9 based therapy has already shown the feasibility of gene editing in treating cancer, but their off target event or unstable efficiency due to the spatiotemporal s pecificity of lncRNA should also be carefully evaluated before further application. Moreover, the combination of nanotechnology and bioinformatics accelerates new nanoparticle development as well as its optimization under clinical conditions via the deep a nalysis of lncRNA functions and distribution. The emergence of new cancer therapeutic strategies worldwide exhibits promise in the treatment of cancer, one of the most serious hum an diseases.
Language Greek, English
Subject Oncogenes
Issue date 2020-08-05
Collection   Faculty/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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