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Identifier

000463280

Title

Functional properties of pyramidal neurons in V1 area in mice with MECP2 duplication syndrome related to contrast and development of a behavioral paradigm for learning

Alternative Title

Λειτουργικές ιδιότητες πυραμιδικών νευρώνων στην πρωτοταγή οπτική περιοχή σε μύες με σύνδρομο διπλασιασμού της πρωτείνης MECP2 και ανάπτυξη συμπεριφορικού πειράματος για τη μελέτη της συναπτικής πλαστικότητας

Author

Σκαρβελάκη, Σταυρούλα

Thesis advisor

Σμυρνάκης, Στέλιος Μ.

Reviewer

Σπανάκη, Κλεάνθη
Φρουδαράκης, Εμμανουήλ

Abstract

Several autism syndromes are the result of abnormal regulation of the expression of specific proteins in cells. Methyl cytosine binding protein 2 (MECP2) is a protein involved in cortical circuit homeostasis in the brain. Duplication of the gene that encodes MECP2, results in MECP2 duplication syndrome. In many syndromes of autism sensory perception is altered, including sensory perception in MECP2 duplication syndrome. This thesis explores the role of MECP2 duplication in contrast perception and contrast response functions of pyramidal neurons in V1 area. Using an animal model of MECP2 duplication syndrome (MECP2 Tg1 mice), we investigated the contrast response functions of V1 pyramidal neurons in MECP2 Tg1 mice and littermate controls in late stages of the disease. In addition, we established a behavioural paradigm for training mice, and we acquired the preliminary data of Visually evoked potential (VEP) recordings in V1 after learning in WT mice

Language

English

Subject

Autism

Plasticity

Αυτισμός

Πλαστικότητα εγκεφάλου

Issue date

2024-04-17

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses