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Identifier 000438372
Title Η έρευνα στο ρετροϊό RSV και στο ογκογονίδιο Src σηματοδότησε την κατανόηση της γενετικής βάσης του καρκίνου
Alternative Title Research on retrovirus RSV and Src ongogene set the fundamentals to understand the genetic basis of cancer
Author Σιμάτου, Αριστοφανία
Thesis advisor Ζουμπουρλής, Βασίλειος
Reviewer Σουρβίνος, Γεώργιος
Αγγελάκη, Σοφία
Abstract Nearly a century after the first discovery of the RSV oncogenic virus by Peyton Rous the proto-oncogene c-Src has emerged as a major regulator of human carcinogenesis, as it is involved in the development, differentiation and acquisition of metastatic phenotype, constituting a potential target for molecular approach against cancer. Despite the fact that the Src gene, is now well studied, molecular pathways through which carcinogenesis is induced have not yet been clarified. The purpose of this dissertation is to highlight through a brief historical background how research on RSV retrovirus and Src proto-oncogene set the fundamentals to understand the genetic basis of cancer and laid the groundwork for the development of targeted anticancer molecules that inhibit tyrosine kinase activity. Furthermore miRNAs and exosomes may contributes an emerging therapeutic strategy of combinational therapies with double pathway inhibition, although further studies are needed. Finally, we suggest that both exosomes and miRNAs could be useful diagnostic, prognostic and predictive biomarkers in Src induced carcinogenesis, thus helping in the more rational and effective classification and treatment of these patients, based on their genetic signature.
Language Greek, English
Subject Cancer therapy
Αντικαρκινική θεραπεία
Ιός του σαρκώματος Rous
Issue date 2021-03-29
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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