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Identifier

000463831

Title

Σαρκώματα μήτρας : Αντιμετώπιση και προγνωστικοί παράγοντες-Μια αναδρομική έρευνα ασθενών από ένα ελληνικό ογκολογικό κέντρο

Alternative Title

Uterine sarcomas

Author

Στρατάκη, Καλλιόπη

Thesis advisor

Μαυρουδής, Δημήτριος

Reviewer

Παπαθεοδώρου, Δημήτριος
Βρεκούσης, Θωμάς

Abstract

Uterine sarcomas are a rare histologically heterogeneous group of tumors, which is associated with an extremely poor prognosis. In the literature to date, there is no agreement regarding the risk factors, the prognosis and the most effective treatment of this aggressive group of mesenchymal tumors . T he purpose of this retrospective study is to describe the experience of a Greek Cancer Hospital in the last decade as well as to study possible factors influencing the prognosis of these aggressive neoplasms. The "Agios Savvas" hospital is an anticancer and oncological center in Athens, with extensive experience in the management and treatment of oncological cases. From the databases of the involved departments of the "Agios Savvas" hospital, all patients with the diagnosis of uterine sarcoma, in the period 2010 2020, were searched and analyzed. The research criteria included: age at diagnosis, histological type, grade of differentiation, initial tumor size, metastatic extension of the disease, type of treatment , and finally disease progression, including data on disease recurrence and disease free interval and overall patient survival by December 2023. In our retrospective study, 28 cases were included, of which fourteen (14) had a histological diagnosis of Leiomyosarcoma (LMS), seven (7) had a diagnosis of Endometrial Stromal Sarcoma (ESS), six (6) had a diagnosis of Undifferentiated Uterine Sarcoma (UU S) and there was one case with a diagnosis of Rhabdomyosarcoma. The mean age at diagnosis was 57.3 years and the mean tumor size 8.7 cm. 57.2% of patients were in Stage I at diagnosis, 10.7% of patients in Stage II, 3.6% of patients in Stage III and 15% in Stage IV. Median overall survival (OS) was 42.8 months while median disease free survival (DFS) for early stage patients was 30.3 months and median progression free survival (PFS) for Stage IV patients was 2 1 months.

Language

Greek, English

Subject

Disease free survival (DFS)

High grade-endometrial stromal sarcomas (HG-ESS)

Leiomyosarcoma (LMS)

Low grade-endometrial stromal sarcomas (LG-ESS)

Overal survival (OS)

Progression free survival (PFS)

Undifferentiated uterine sarcomas(UUS)

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