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Identifier 000361249
Title Investigating the link between cell cytoskeleton, P-bodies and ageing in Caenorhabditis elegans
Alternative Title Μελέτη της πιθανής σχέσης του κυτταροσκελετού με τα P-bodies και τη γήρανση στο νηματώδη Caenorhabditis elegans
Author Μυλωνάκη, Αδαμαντία Ιω.
Thesis advisor Ταβερναράκης, Νεκτάριος
Abstract Ageing is the biological phenomenon by which a fit and healthy organism changes into a less healthy and fit one for its environment. It is accompanied by specific age-related characteristics, like the inability to maintain tissue homoeostasis [19]. In humans, ageing is associated with a subset of diseases including neurodegeneration, cardiovascular disorders and others. As the human life expectancy has been increased, more people live long enough to suffer from age-related loss of function and disease. Unveiling the mechanisms of ageing, will hopefully give answers about how science could deal with the age-related diseases. In this work, we aim to investigate the relationship between ageing, microtubules and P-bodies. Microtubules provide critical functions in cells, including mechanical support, intracellular trafficking and others [31]. P-bodies are dynamic, non-membrane structures that host different types of mRNA processing [40]. In this work, we show that ageing in C. elegans could be accompanied by P-body induction and that microtubule disruption maybe leads to the opposite effect. Hopefully, research in this field, will further shed light on the mechanisms of ageing, and the ageing-related diseases.
Language English
Subject C. elegans
Issue date 2010-11-19
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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