Post-graduate theses

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Identifier	000039992
Title	Σχεδιασμός, συνθετικές προσεγγίσεις και σύνθεση φθορίζοντος δείκτη Ζn2+ τύπου
Alternative Title	Design, synthetic approaches and total synthesis of a New TREN-type FLuorescent Zinc Probe
Author	Δακανάλη, Μαριάννα
Thesis advisor	Κατερινόπουλος, Χαράλαμπος
Abstract	The major goal of this thesis was the design, the synthetic approaches, and the total synthesis of a coumarin-type fluorescent Zn2+ probe. The structure of the probe is comprised of a fluorophore namely, 2-amino-4-methylcoumarin connected to TREN, a known selective Zn2+ chelator. The choice of the chromophore was based on the fluorescence spectral profile of the coumarin analog, as well as on the respective restrictions posed by the type of the desired zinc-probe applications and the necessary instrumentation. The chelator was selected on the basis of its affinity to zinc ions and its selectivity to Zn2+ versus other ions present in the systems of study. This thesis also includes a set of preliminary experiments aiming at the study of the formation of N,N-disubsituted 2-aminoethyl formates during the reaction of N,N-disubstituted 2-bromoethylamines with DMF in the presence of DIPEA. A tentative reaction mechanism is proposed as well as a number of substrates to be studied in order to ascertain the detailed mechanism of the reaction.
Language	Greek
Issue date	2004-06-11
Collection	School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/e/1/5/metadata-dlib-2004dakanali.tkl
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