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Identifier	000361249
Title	Investigating the link between cell cytoskeleton, P-bodies and ageing in Caenorhabditis elegans
Alternative Title	Μελέτη της πιθανής σχέσης του κυτταροσκελετού με τα P-bodies και τη γήρανση στο νηματώδη Caenorhabditis elegans
Author	Μυλωνάκη, Αδαμαντία Ιω.
Thesis advisor	Ταβερναράκης, Νεκτάριος
Abstract	Ageing is the biological phenomenon by which a fit and healthy organism changes into a less healthy and fit one for its environment. It is accompanied by specific age-related characteristics, like the inability to maintain tissue homoeostasis [19]. In humans, ageing is associated with a subset of diseases including neurodegeneration, cardiovascular disorders and others. As the human life expectancy has been increased, more people live long enough to suffer from age-related loss of function and disease. Unveiling the mechanisms of ageing, will hopefully give answers about how science could deal with the age-related diseases. In this work, we aim to investigate the relationship between ageing, microtubules and P-bodies. Microtubules provide critical functions in cells, including mechanical support, intracellular trafficking and others [31]. P-bodies are dynamic, non-membrane structures that host different types of mRNA processing [40]. In this work, we show that ageing in C. elegans could be accompanied by P-body induction and that microtubule disruption maybe leads to the opposite effect. Hopefully, research in this field, will further shed light on the mechanisms of ageing, and the ageing-related diseases.
Language	English
Subject	C. elegans
	Microtubules
	Μικροσωληνίσκοι
Issue date	2010-11-19
Collection	School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/f/b/4/metadata-dlib-2c33d466761b9c498411e50696841f6f_1286874515.tkl
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