Post-graduate theses
Current Record: 5406 of 6568
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| Identifier |
000419783 |
| Title |
Stydy of myelinophagy in oligodendrocytes. |
| Alternative Title |
Μελέτη της αυτοφαγίας στα ολιγοδενδροκύτταρα κατά τη μυελίνωση |
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Author
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Κτενά, Νίκη
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Thesis advisor
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Καραγωγέως, Δόμνα
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Reviewer
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Νικολετοπούλου, Βασιλική
Χαραλαμπόπουλος, Ιωάννης
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| Abstract |
Autophagy comprises a conserved lysosome-dependent catabolic pathway, facilitating degradation of cytoplasmic proteins and damaged organelles. Through its role in energy production and in maintaining cellular homeostasis, autophagy is crucial during development as shown in many tissues and organisms. Its dysregulation has been linked to several disorders, including neurodegenerative diseases, and more recently demyelinating disorders affecting mainly the PNS.
Myelin, produced by oligodendrocytes (OLs) in the CNS, provides mammals with an evolutionary advantage that insulates the axon, provides trophic support and ensures the rapid and efficient propagation of action potentials along its length. Its disruption, namely demyelination, may occur as a consequence of aging, from genetic alterations in genes encoding myelin proteins (dysmyelination) or from an inflammatory response against myelin producing cells, as is the case in Multiple Sclerosis (MS).
The present study aimed to shed light on the significance of autophagy in the myelinating glia in the central nervous system (CNS). More specifically, we examined the role of autophagy in both oligodendrocyte precursor cells and mature oligodendrocytes, using in vitro approaches.
In the first part of this study, we showed that autophagy is active in OPCs and that its pharmacological inhibition causes translocation of the autophagy cargo receptor p62 to the nucleus and increased proliferation. Subsequently, in the second part of the study, we proved that autophagy is also active in mature oligodendrocytes and inhibition of autophagy leads to severe morphological defects in the myelin sheath of these cells. These observations strongly support that autophagy is an essential mechanism for central myelin formation and maintenance and propose the principle that the progression of myelination in the CNS requires the involvement of a fully functional autophagic machinery.
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| Language |
Greek, English |
| Subject |
Autophagy |
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Myelin |
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Αυτοφαγία |
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Μυελίνη |
| Issue date |
2018-12-05 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/2/3/9/metadata-dlib-1545036056-562538-24212.tkl
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| Views |
309 |
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