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Identifier

000421471

Title

Ορολογικός έλεγχος συγγενών λοιμώξεων στην κύηση : Βενιζέλειο Γενικό Νοσοκομείο Ηρακλείου , 2018

Alternative Title

Seroprevalence of perinatal infections in pregnancy

Author

Στεφανάκη, Ευαγγελία

Thesis advisor

Δημητρίου, Ελένη

Reviewer

Γαλανάκης, Εμμανουήλ
Βρεκούσης, Θωμάς

Abstract

Introduction-Object: Congenital infections are those transmitted from mother to child intrapartum, during or after labour. They are major cause of prenatal and infantile morbidity and mortality. The most important congenital infections comprise in TORCH acronymion and are toxoplasmosis, infection by cytomegalovirus (CMV), rubella, hepatitis B and C viruses (HBV,HCV) ,herpes simple virus(HSV), human immunodeficiency virus(HIV) and others like varicella and Parvo B19 virus. Prenatal seroprevalence testing and high index of clinical suspicion could help reduce complications on embryos and infants. The relative small number of recent studies on seroprevalence of congenital infections in Greece is the cause of our study. Methods: Data of pregnant women who gave birth in Venizeleion General Hospital of Heraklion between 1st January of 2018 and 31st December of 2018 were studied retrospectively. Results on seroprevalence testing during pregnancy were searched in medical records. Specifically were searched IgG and IgM for Toxoplasma gondii, CMV, rubella, HBsAg, antiHCV , specific antibodies for syphilis(antiTP) and HIV testing. Results: The study included 1020 pregnant women and with median age 29 years. Most of the women (83%) were of Greek origin. A percentage of 10% of the foreign pregnant women were refugees from Syria. The prevalence of positive HBsAg was 6/677 (0.89% 95% CI 0.41-1.93) with 0.53% in Greek women. The prevalence of HCV was 2/678 (0.29% 95% CI 0.08-1.06).One Greek woman was found positive for HIV (0.15% 95% CI 0.03-0.84). Noone was found positive for syphilis. The prevalence of CMV was 66% (95% CI 62.35-69.5). Statistically the most significant difference was recorded between women from Greece and Albania (p<0.005 ). Seroconversion during pregnancy was recorded in 0.84% (95% CI 0.34-1.92). The prevalence of T.gondii was 18.73 % (95% CI 15.97-21.84). The prevalence in Greek women was 15.18% (95% CI 12.47-18.35). The difference in prevalence was statistically significant between Greek women and those from Albania, Syria, Romania and women from countries of Eastern Europe. (p<0.005 ). Seroconversion during pregnancy was recorded in 0.42%. The prevalence for positive IgG rubella antibodies was 83.73% ( 95% CI 80.65-86.4). On the other hand 16.27% ( 95% CI 13.6-19.35) of pregnant women were found to be in danger of getting ill from rubella. The lower statistically significant percentage of prevalence was recorded in the age group < 20 years (p<0.005 ). Conclusions: The seroprevalence percentages for hepatitis B and C are in agreement with the ones already recorded for Greece. No case of syphilis and only a single case of HIV infection were recorded . Seroprevalence for CMV was in high levels and stable comparing with previous studies. Expected statistical differences were recorded between nationalities . The prevalence for T.gondii was recorded lower comparing with previous studies and also statistically significantly lower in Greek women comparing with other nationalities. The percentage of women negative for IgG antibodies to rubella was higher than the accepted lower limit, especially in the age group <20 years but without recorded increase in rubella cases in the country. Missing data lowered the size of a relatively large population of pregnant women. Multicenter studies could improve the quality of epidemiological data on in Greece and support changing public policies on prevention of congenital infections.

Language

Greek

Subject

Cytomegalovirus

HIV

Hepatitis B

Hepatitis C

Rubella

Syphilis

Toxoplasma gondii

Επιπολασμός

Ερυθρά