E-Locus - Institutional Repository of the University of Crete

Home Collections Type of Work Post-graduate theses

Post-graduate theses

Current Record: 6512 of 6563

[Add to Basket]

Identifier

000446700

Title

Study of mena-RNP complex in the developing brain

Alternative Title

Μελέτη του Mena-RNP συμπλόκου στον αναπτυσσόμενο εγκέφαλο

Author

Δακλαδά, Ελισάβετ

Thesis advisor

Βιδάκη, Μαρίνα

Reviewer

Καραγωγέως, Δόμνα
Χαραλαμπόπουλος, Ιωάννης

Abstract

Development and growth of the nervous system are complex processes that require neurons to extend their axons, reach their targets and form functional networks. Any mistake at these processes can lead to neurodevelopmental or cognitive disorders. Local mRNA translation is one of the main molecular mechanisms for axonal guidance, synaptogenesis and maintenance of neuronal networks and understanding the regulation of this mechanism will uncover many other aspects of the development and regeneration of the nervous system as well as neurodevelopmental diseases. Studying the actin-regulatory protein Mena and its RNP complex in the regulation of local translation of mRNAs that are involved in the ribonucleoprotein complex in the developing axons, may reveal important information about the process of axonal translation in the developing neurons.

Language

English

Subject

Axon guidance

Local translation

Spina code

Αξονική καθοδήγηση

Issue date

2020-03-30

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses