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Identifier 000460567
Title Hilar mossy in human patients and a mouse model of Frontotemporal Dementia
Alternative Title Ο ρόλος των πυλαίων βρυωδών κυττάρων στη μετωποκροταφική άνοια
Author Κοκοσάλη, Ευγενία
Thesis advisor Maria Llorens- Martin
Reviewer Χαραλαμπόπουλος, Ιωάννης
Ζαγανάς, Ιωάννης
Abstract Frontotemporal Dementia (FTD) is a neurodegenerative disorder that involves the progressive degeneration of the frontal and temporal lobes, with the patients displaying behavioural or language symptoms. Frontotemporal Dementia and Parkinsonism linked to chromosome 17 (FTDP-17) is a subtype of FTD that falls into the category of tauopathies. Mutations in the MAPT gene are associated with this disorder. Hilar Mossy Cells (MCs), a glutamatergic subtype of neurons of the dentate gyrus (DG), are implicated in several pathological conditions like Temporal Lobe Epilepsy (TLE), Schizophrenia (SCZ) and Alzheimer’s Disease (AD). In this project, we studied the changes in MCs in a transgenic mouse model of FTDP-17 (TauVLW), harbouring mutations in the MAPT gene, and in human patients of FTD. We found that, compared to control mice, TauVLW mice show a decreased volume of both the dorsal and ventral DG, and a decrease in the number of MCs in the ventral DG. We also showed that the expression of Calretinin (CR), which is considered a gold-standard marker for MCs, follows a latero-medial gradient in the dorsal DG. In patients with FTD, the density of CR+ MCs showed no changes compared to healthy control subjects; however, we found a decrease in the densities of CR+ immature dentate granule cells (DGCs) and CR+ interneurons. By performing qualitative determinations, we showed that distinct subpopulations of MCs, expressing different molecular markers, are present in the human DG. Together, these data suggest that MCs are vulnerable to neurodegeneration mechanisms present in mouse models and patients with FTD. Further investigation is needed to shed light on the underlying mechanisms behind MC loss and/or dysfunction.
Language English
Subject Calretinin (CR)
Dysbindin-1C
Tauopathies
Βρυώδη κύτταρα
Δυσμπινδίνη-1C
Καλρετινίνη (CR)
Ταυοπάθειες
Issue date 2023-12-08
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/4/f/f/metadata-dlib-1700820259-864013-22404.tkl Bookmark and Share
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