E-Locus - Institutional Repository of the University of Crete

Home Collections Type of Work Post-graduate theses

Post-graduate theses

Current Record: 5083 of 6558

[Add to Basket]

Identifier

000369231

Title

Μοριακή ανάλυση των διαλυτών MHC τάξης ΙΙ μορίων και ο ρόλος τους στην ρύθμιση των Τ-λεμφοκυττάρων

Alternative Title

Molecular analysis of soluble MHC-II molecules and their role in T-cells regulation

Author

Μπακέλα, Κατερίνα

Thesis advisor

ΑΘανασάκη, Ειρήνη

Abstract

Soluble MHC-II molecules are present in body fluids of healthy individuals but are also connected and studied in various diseases, whereas are involved in immune tolerance. Soluble MHC-II were isolated from the serum of mice, tolerized with HSA and were examined for their ability to affect responsiveness of total spleencells and T-cells. In this present study, we have shown that the soluble molecules are capable to suppress an immune reaction, mounted against an antigenic stimulus by reducing the number of active cells. Furthermore, these molecules have the ability to induce the secretion of the cytokine IL-10 while stimulating the proliferation of CTLA-4+ cells that are related to suppression, through the negative regulation of CD4+ and CD28+ cells. We propose that these molecules play a very important role in antigen-specific tolerance, also known as clonal anergy.

Language

Greek

Subject

IL-10

Repression

Tolerance

Καταστολή

Issue date

2011-11-18

Collection

School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses

Type of Work--Post-graduate theses