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Identifier

000466737

Title

Structure and dynamic properties of collagen-based formulations

Alternative Title

Δομή και δυναμικές ιδιότητες αιωρημάτων βασισμένων σε κολλαγόνο

Author

Λυρώνη, Κωνσταντίνα

Thesis advisor

Βλασσόπουλος, Δημήτριος
Choitre, Michel

Abstract

Collagen type I, due to its plethora of applications in the biomedical field for tissue regeneration in the form of scaffolds, is a well-studied material regarding its structure and properties in the final construct. However, there is lack of knowledge in the pristine suspension and especially a link to the microstructure and its bulk rheological behavior that is essential for the scaffold viability. In this master’s thesis, we try to correlate the microstructure characteristics of the collagen fibers such as the fiber crystallinity, diameter, and the mesh size, with the rheological response of the material like its viscoelasticity, its modulus and its flow behavior. For this purpose, confocal microscopy was utilized for the structural visualization of the collagen fibers, and was associated to the experimental results of rheology and particle image velocimetry to gain more insights in the unknown nature of this material in terms of structure-related properties. Lastly, experimental parameters that can alter the numerical values of the data acquired both in confocal microscopy, and rheometry were evaluated.

Language

English

Subject

Microscopy

Rheology

Μικροσκοπία

Προφίλ ταχύτητας

Ρεολογία

Σκέλαση φωτός

Issue date

2024-07-24

Collection