Post-graduate theses
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Identifier |
000395491 |
Title |
Χρήση φαρμάκων κατά την εγκυμοσύνη και συμπτώματα άσθματος στην παιδική ηλικία : ανάλυση δεδομένων από τη μελέτη Μητέρας- Παιδιού Κρήτης "Ρέα" |
Alternative Title |
Medication's use during pregnancy and ashma symptoms in childhood |
Author
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Αλεξάκη, Μαρία Ε.
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Thesis advisor
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Χατζή, Λ.
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Reviewer
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Ρουμελιωτάκη, Θ.
Βαφειάδη, Μ
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Abstract |
Medication use (prescribed or not) by pregnant women has increased in recent years. The majority of consumed drugs could affect the fetus, while their mechanism of action is object of extensive research. Simultaneously, the prevalence of childhood asthma is increasing worldwide. The purpose of this study is to describe frequencies and determinants of drug use during pregnancy and also to examine possible correlations between used medications and the occurrence of asthma symptoms in children aged 9 months and 4 years. The study population is part of the “Rhea” Mother-child Cohort in Crete, Greece. Pregnant women completed questionnaires on medication use during a personal interview at the first and the second trimesters of pregnancy. The most frequent drug used in first and second trimester of pregnancy was paracetamol (16%) and the second was progesterone (15%). In the present analysis, use of antibiotics in the first two trimesters of pregnancy was associated with increased risk of offspring wheeze at 9 months of age (RR 1,57; 95% CI: 1,17 - 2,1), while use of acetylsalycylic acid was associated with increased risk of wheeze ever (RR 3,32 ; 95% CI: 1,46 - 7,54), current asthma (RR 3,31; 95% CI: 1,41 - 7,78) and current rhinoconjuctivitis (RR 2,87; 95% CI: 0,98 - 8,4) in the age of 4 years. No association was found between prenatal intake of paracetamol and asthma symptoms in early childhood. The present analysis highlights the importance of drug use in pregnancy in the prevention of allergic diseases in childhood.
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Language |
Greek |
Subject |
Prescribed drugs |
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Συνταγογραφημένα φάρμακα |
Issue date |
2015-07-17 |
Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/f/d/2/metadata-dlib-1441887505-967066-32358.tkl
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Views |
192 |