E-Locus - Institutional Repository of the University of Crete

Home Collections Type of Work Post-graduate theses

Post-graduate theses

Current Record: 5188 of 6553

[Add to Basket]

Identifier

000395491

Title

Χρήση φαρμάκων κατά την εγκυμοσύνη και συμπτώματα άσθματος στην παιδική ηλικία : ανάλυση δεδομένων από τη μελέτη Μητέρας- Παιδιού Κρήτης "Ρέα"

Alternative Title

Medication's use during pregnancy and ashma symptoms in childhood

Author

Αλεξάκη, Μαρία Ε.

Thesis advisor

Χατζή, Λ.

Reviewer

Ρουμελιωτάκη, Θ.
Βαφειάδη, Μ

Abstract

Medication use (prescribed or not) by pregnant women has increased in recent years. The majority of consumed drugs could affect the fetus, while their mechanism of action is object of extensive research. Simultaneously, the prevalence of childhood asthma is increasing worldwide. The purpose of this study is to describe frequencies and determinants of drug use during pregnancy and also to examine possible correlations between used medications and the occurrence of asthma symptoms in children aged 9 months and 4 years. The study population is part of the “Rhea” Mother-child Cohort in Crete, Greece. Pregnant women completed questionnaires on medication use during a personal interview at the first and the second trimesters of pregnancy. The most frequent drug used in first and second trimester of pregnancy was paracetamol (16%) and the second was progesterone (15%). In the present analysis, use of antibiotics in the first two trimesters of pregnancy was associated with increased risk of offspring wheeze at 9 months of age (RR 1,57; 95% CI: 1,17 - 2,1), while use of acetylsalycylic acid was associated with increased risk of wheeze ever (RR 3,32 ; 95% CI: 1,46 - 7,54), current asthma (RR 3,31; 95% CI: 1,41 - 7,78) and current rhinoconjuctivitis (RR 2,87; 95% CI: 0,98 - 8,4) in the age of 4 years. No association was found between prenatal intake of paracetamol and asthma symptoms in early childhood. The present analysis highlights the importance of drug use in pregnancy in the prevention of allergic diseases in childhood.

Language

Greek

Subject

Prescribed drugs

Συνταγογραφημένα φάρμακα

Issue date

2015-07-17

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses

Permanent Link

https://elocus.lib.uoc.gr//dlib/f/d/2/metadata-dlib-1441887505-967066-32358.tkl