Doctoral theses
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Identifier |
000465807 |
Title |
Wavefront shaping for microscopic imaging of biological samples |
Alternative Title |
Διαμόρφωση μετώπου κύματος για μικροσκοπική απεικόνηση βιολογικών δειγμάτων |
Author
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Μυλωνάκης, Μιχαήλ
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Thesis advisor
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Ζαχαράκης, Ιωάννης
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Reviewer
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Παπάζογλου, Δημήτιος
Τζωρτζάκης, Στυλιανός
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Abstract |
Imaging of biological samples is one of the driving application fields of optical
microscopy. Although several other imaging techniques have been developed the
simplicity, the effectiveness and the non-invasive nature of optical microscopy are the
key factors of its widespread use in Biology.
An important limiting factor for optical microscopy is the scattering of light as
it propagates through biological tissue. The inherent random variations of the optical
properties, lead to a diffusion dominated propagation that drastically limits the effective
imaging range down to 1 mm. On the other hand, recent advances in the spatial
modulation of the light beam that illuminates the sample combined with analysis of the
detected light distribution have opened the way to beat the diffusion limit.
Τhis PhD thesis was focused on leveraging the concept of the 'opaque lens' by
utilizing engineered disorder in photonic structures. This involved developing novel
scattering media and their integration with wavefront shaping into imaging modalities.
Using this approach, we have reached to the development of a fully functional
fluorescence microscope that, in several aspects, outperforms current
instrumentation capable of performing in vivo fluorescence microscopy.
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Language |
English |
Subject |
Bioimaging |
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Optics |
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Βιοαπεικόνιση |
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Οπτική |
Issue date |
2024-07-24 |
Collection
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School/Department--School of Sciences and Engineering--Department of Materials Science and Engineering--Doctoral theses
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Type of Work--Doctoral theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/4/f/f/metadata-dlib-1719908321-840109-21204.tkl
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Views |
215 |
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