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Title Σύνθεση και μελέτη βιολογικής δραστηριότητας παραγώγων του 2-άμινο-1,2,3,4-τετράυδρο-1,4-εποξυναφθαλενίου και 2,3,6,7A,8,12B,12C-οκτάυδρο-1H,5H,-νάφθο[1,2,3,I,J]κινολιζίνης, δύσκαπτων αναλόγων της ντοπαμίνης
Alternative Title Synthesis and biological studies of 2-amino-1,2,3,4-tetrahydro-1,4-epoxynaphthalene and 2,3,6,7A,12B,12C-octahydro-1H,5H-naphtho[1,2,3,I,J]quinolizine, rigid analogues of dopamine
Author Κουβαράκης, Αντώνης Ν
Abstract In this thesis is described the synthetic methodology tha was chosen for the preparation of a series of dopamine (DA) analogues. The first group includes the synthesis of a series of analogues of 2-amino-1,2,3,4-tetrahydro-1,4-epoxy-naphthalene. These compounds can be considered as analogues of the DA-active compound ADTN. The second group includes the total diastereoselective synthesis of the tetracyclic analogue of Dopamine 2,3,6,7a,8,12b,12c-octahydro-1h,5h-naphtho[1,2,3,i,j]quinolizine with trans-cis fusion of the ring B/C and B/D respectively. The results of biological studies of these compounds are discused in basis of the relation between their structural characteristics and their activity.
Language Greek
Issue date 1995-04-01
Date available 1997-06-6
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Chemistry--Doctoral theses
  Type of Work--Doctoral theses
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