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Identifier

000031770

Title

Μη σεμινωματώδεις όγκοι του όρχεος από αρχέγονα εμβρυκά κύτταρα. Η συμβολή της υπολογιστικής τομογραφίας στην εκτίμηση της πρώιμης ανταπόκρισης στη χημειοθεραπεία

Creator

Tsetis, Dimitris K

Abstract

The aim of this study is to investigate the predictive value of Computed Tomography (CT) during the early phase of induction chemotherapy - and more specifically at day 21 -in a subgroup of patients with metastatic testicular nonseminomatous germ - cell tumours (NSGCT) of favourable prognosis, according to specific criteria (" good - risk patients"). The study is focused on: a) The early identification of those patients who will need postchemotherapy surgical excision of residual disease, in order to schedule properly this difficult surgical procedure and b) The reduction in the total amount of chemotherapy and in particular of the number of cycles (from 4 to 3). Twenty - six (26) patients with metastatic testicular NSGCT undergoing induction chemotherapy were studied. The site of maximum disease was detected at day 21. The change in disease bulk, measured as maximum transverse diameter (MTD), was compared with appearances on a CT scan immediately after chemotherapy and post - treatment response. Of those patients showing o poor response on the day 21 scan (i.e. no change, or less than 50% reduction in MTD), 70% required early surgical excision of residual disease, while none of the good responders (i.e. greater than 50% reduction in MTD), required immediate surgery (p<0.001). It is concluded that a limited day 21 CT scan may represent an independent predictor of good and poor response to chemotherapy, thus enabling reduction in chemotherapy and its toxicity in good responders and early identification of those who may need surgical excision, thereby permitting easier scheduling of these often difficult surgical procedures.

Language

Greek

Issue date

1998-12-01

Date available

1999-02-10

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

Permanent Link

https://elocus.lib.uoc.gr//dlib/b/7/4/metadata-dlib-1998tsetis.tkl