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Identifier 000430948
Title Η μελέτη της λειτουργίας των μικρών αεραγωγών στο σύνδρομο αποφρακτικών απνοιών-υποπνοιών στον ύπνο (ΣΑΑΥY)
Alternative Title The study of the function of small airways in obstructive sleep apnea hypopnea syndrome (OSAHS)
Author Γιανναδάκη, Αικατερίνη Γ.
Thesis advisor Σιαφάκας, Νικόλαος
Reviewer Σχίζα, Σοφία
Κατσουγιάννη Κλέα
Abstract Background Most of the studies of the pathophysiology of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) are focusing in the collapsibility and obstruction of the upper airways. The aim of our study was the investigation of small airways’ function in patients with OSAHS. Methods We studied 23 patients (mean age, 51.6 years) diagnosed with mild to severe OSAHS, without comorbidities and 8 controls (mean age, 45.9 years). All subjects underwent full polysomnography sleep study; spirometry and maximum flow/volume curves while breathing room air and a mixture of 80%He-20%O2. The volume of equal flows (VisoV̇) of the two curves and the difference of flows at 50% of FVC (ΔV̇max50) were calculated, as indicates of small airways' function. Results The results showed that VisoV̇ was significantly increased in patients with OSAHS compared with controls (18.79 ± 9.39 vs. 4.72 ± 4.68, p=0.004). No statistically significantly difference was found in ΔVmax50 (p=0,551); or the maximum Expiratory flow at 25-75% of FVC (p=0,067) and the maximum expiratory flow at 50% of FVC (p=0,174) breathing air. Conclusion We concluded that at the time of diagnosis of OSAHS, the function of small airways is affected. This could be due to breathing at low lung volumes and the cyclic closure/opening of the small airways and may affect the natural history of OSAHS. The findings could lead to new therapeutic implications, targeting directly the small airways
Language Greek
Subject Pathophysiology of respiratory system
Sleep medicine
Sleep pathophysiology
Ιατρική του ύπνου
Παθοφυσιολογία ύπνου
Issue date 2020-08-05
Collection   Faculty/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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