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Identifier uch.med.phd//1994merkouris
Title Απομόνωση και χαρακτηρισμός ενός Δ-τύπου οπιοείδους υποδοχέα από μεμβράνες εγκεφάλου του επιμυός
Alternative Title Isolation and characterization of a Δ-type opioid receptor from rat brain membranes
Creator Merkouris, Emmanouel P
Abstract This work is aiming at the isolation, biochemical study and characterization of opioid receptors in rat central nervous system using three different biological preparations A)rat brain synaptosomal membranes, B)synaptosomal membranes solubilized with DOCNA, C)the isolated receptor by affinity chromatography with the affi-nal resin. The results are summarized below: I)solubilization of active opioid receptors in high yield with binding parameters for agonists and antagonists which are close to those of the synaptosomal preparation. II)isolation of active receptors, using affi-nal affinity chromatography, the bound selectively Δ-opioid ligands. III)generation of polyclonal antibodies against the isolated Δ-opioid receptor followed by further characterization of the receptor using the partially purified antibodies.
Issue date 1994-12-01
Date available 1997-06-6
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/b/4/0/metadata-dlib-1994merkouris.tkl Bookmark and Share
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