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Identifier 000426362
Title Regulation of gene expression in cis and in trans
Alternative Title Ρύθμιση της γονιδιακής έκφρασης σε cis και trans
Author Piwko, Pawel S.
Thesis advisor Δελιδάκης, Χρήστος
Reviewer Σπηλιανάκης, Χαράλαμπος
Καλαντίδης, Κρίτων
Αλεξανδράκη, Δέσποινα
Παπαματθαιάκης, Ιωσήφ
Τζαμαρίας, Δημήτριος
Γαρίνης, Γεώργιος
Abstract bHLH-Orange proteins, like the mouse Hes and the Drosophila Enhancer of split [E(spl)] proteins are transcription factors that, among a multitude of functions, are implicated in maintaining the undifferentiated state in many stem-cell based systems. For instance, they antagonize bHLH proneural activators and suppress neural fate. Their levels have to be exquisitely regulated to achieve a precise balance between proliferation and differentiation. For this reason they are subject to multi-tiered regulation. During my PhD research I have tried to understand how the expression of two neighboring E(spl) genes, E(spl)m7 and E(spl)m8, is regulated and how this regulation impacts biological processes controlled by their protein products. I have provided description of their enhancer, promoter and 3' untranslated elements and scrutinized the role of these elements in specifying spatio-temporal abundance of the E(spl)m7 and E(spl)m8 proteins. I demonstrate that compromising transcriptional negative autoregulation and translational repression can 2 have dramatic consequences on the expression levels and the activity of these two genes. Thus, both regulatory modes are essential in determining level-dependent functions of E(spl)m7 and E(spl)m8.
Language English
Subject Drosophila
Homologous pairing
Ζεύξη ομολόγων χρωμοσωμάτων
Issue date 2019-11-29
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Biology--Doctoral theses
  Type of Work--Doctoral theses
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