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Identifier 000429988
Title Quantitative evaluation of perfusion studies with non-ionizing (MRΙ) and low dose radiation (CT) protocols
Alternative Title Ποσοτική εκτίμηση μελετών αιματικής διήθησης με πρωτόκολλα απεικόνισης Μαγνητικού Συντονισμού (ΜRI) και Υπολογιστικής Τομογραφίας (CT) χαμηλής ακτινικής επιβάρυνσης
Author Ιωαννίδης, Γεώργιος Σ.
Thesis advisor Χατζηδάκης, Αδάμ
Reviewer Περυσινάκης, Κωνσταντίνος
Μαριάς, Κωνσταντίνος
Abstract One of the most vital parameters of biological tissues is the blood flow. The growth and the functionality of many organs are related directly with their blood supply. Many diseases are related with the increase or the decrease of the blood flow compared to the physiological values as well with the architecture of the blood vessel network. For this reason, the development of non-invasive tools for the measurement of blood flow is of crucial significance. Firstly, in this work pharmacokinetic models, according to the literature, were developed for the extraction of quantitative and semi-quantitative perfusion parameters for every imaging technique (perfusion MRI, Diffusion Weighted Imaging, perfusion CT). A first aim of this thesis is the study of the possible correlation between perfusion related parameters coming from perfusion MRI and Diffusion MRI with the ultimate goal to reduce the number of perfusion examinations requiring intra-venous injection of gadolinium based contrast agent. Secondly, despite a worldwide effort to standardize imaging bio-markers involving major cancer organizations, significant variability of MR-based imaging biomarker across sites still hampers their clinical translation calling for more research in the field. To this end, the second clinical question covered in this thesis is to study quantitative and semiquantitative approaches for perfusion biomarkers are compared in MRI data from three different cancer types. In particular, Ktrans a widely used but often variable across sites candidate biomarker is compared to a semi-quantitative perfusion MRI imaging biomarker (Wash-in WIN) in patients involving three cancer types: breast, head and neck and soft tissue sarcoma Finally, the third goal of this thesis is to investigate the possibility to introduce lower dose protocols by decreasing the image data sampling rate and the tube current during brain CT perfusion studies on stroke patients without affecing the diagnostic efficiency of the produced perfusion parametric maps.
Language English
Subject Perfusion CT
Perfusion MRI
Quantitative MRI
Issue date 2020-08-05
Collection   Faculty/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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