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Identifier uch.med.phd//2002traka
Title Ο ρόλος της νευρωνικής πρωτεΐνης συνάφειας ΤΑG-1 στις αξονο-γλοιακές αλληλεπιδράσεις στην ανάπτυξη και αναγέννηση του νευρικού συστήματος
Creator Traka, Maria
Abstract TAG-1 is a neural adhesion protein of Immunoglobulin Superfamily (IgCAM) that is linked to the plasma membrane through a glycosylphosphatidylinositol (GPI) anchor. The expression pattern of TAG-1 has been extensively studied mainly during the embryonic development, where it is expressed in specific neuronal sub-populations immediately after their differentiation. Its expression is implicated in axonal growth and guidance as well as in neuronal migration. In addition, the TAG-1 mRNA had been detected in adult central nervous system (CNS), but these studies lacked a detailed analysis of TAG-1 expression and in the case of the peripheral nervous system, no such studies were performed. In this study, a detailed analysis of TAG-1 is presented in adult dorsal root ganglion (DRG) neurons, where it is detected at lower levels as compared to earlier stages. TAG-1 expressed in the cell bodies of the previous neurons could mediate the formation and maintenance of contact between neurons and their satellite glial cells in the DRG capsule. At the same time, protein expression is detected in the projections of these neurons, in which its reduction during development could signal the formation or the final differentiation of myelin sheath around the larger diameter axons. The central innervation target of DRG neurons (spinal cord) is important for the maintenance of proper TAG-1 expression, since the absence of this target in the in vivo model of excitotoxic lesion, results in the significant reduction of TAG-1 protein levels in the cell bodies and the peripheral projections of injured neurons. During DRG regeneration in the in vivo model of unilateral sciatic nerve axotomy, there is no increase of TAG-1 levels at the initial stages of axonal sprout formation. The continuous concentration of TAG-1 in DRGs is possibly correlated with the high regeneration efficiency of these neurons. In more advanced stages of regeneration, we observe a significant reduction of TAG-1 that might be caused by the interactions of axonal sprouts with the Schwann cell substrate at the distal nerve stump. The persisting reduction of TAG-1 possibly contributes to the further elongation and guidance of regenerating axons to their original targets.
Issue date 2002-07-01
Date available 2002-12-23
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/c/2/3/metadata-dlib-2002traka.tkl Bookmark and Share
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