Doctoral theses
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| Identifier |
290877 |
| Title |
Μελέτη του μορίου κυτταρικής συνάφειας TAG-1 στην ανάπτυξη του φλοιού του τελεγκεφάλου |
| Creator |
Denaxa, Myrto
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| Abstract |
The forebrain comprises an intricate set of structures that are required for some of the most complex and evolved functions of the mammalian brain. As a reflection of its complexity, cell migration in the forebrain is extremely elaborated, with widespread dispersion of cells across multiple functionally distinct areas. Two general modes of migration are distinguished in the forebrain: radial migration and tangential migration. During the formation of the cerebral cortex, cortical nonpyramidal cells, the GABA-containing interneurons, originate mostly in the medial ganglionic eminence (MGE) of the ventral telencephalon and follow tangential migratory routes to reach the dorsal telencephalon. Although several genes that play a role in this migration have been identified, the underlying cellular and molecular mechanism is not fully understood. In the present study, we examined the role of the neural cell adhesion molecule TAG-1 in the migration of cortical interneurons. We showed that the migration of these neurons occurs along the TAG-1-expressing axons of the developing corticofugal system. Blocking in vitro the function of TAG-1 resulted in a marked reduction of GABAergic neurons in the cortex. These observations reveal a mechanism by which the adhesion molecule TAG-1, known to be involved in axonal pathfinding, also takes part in neuronal migration. We furthermore studied the expression pattern and role of other adhesion molecules and known partners for TAG-1 in this migratory system. We showed that most of the proteins examined, are unlikely to be involved in the migration of GABAergic interneurons, thus, a new unidentified partner for TAG-1 mediates its function during this migratory process. Finally, to directly address the role of TAG-1 protein in the guidance of cells tangentially migrating from the subpallium to the cortex, we studied mice deficient for TAG-1. No alterations have been observed in the migration of cortical intereurons or the distibution of corticofugal axons, in the telecenphalon of the mutant mice. The above results show that TAG-1 does not seem to be required in vivo for the tangential migration of GABAergic interneurons and other molecules involved in this migratory mechanism can compensate for the loss of the TAG-1 protein.
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| Language |
Greek |
| Issue date |
2004-07-01 |
| Date available |
2004-10-14 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Doctoral theses
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Type of Work--Doctoral theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/c/5/1/metadata-dlib-2004denaxa.tkl
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| Views |
273 |
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