Doctoral theses
Current Record: 1986 of 2443
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| Identifier |
uch.med.phd//2001pomonis |
| Title |
Η ελικώδης κολίτις στην Ελλάδα. Επιδημιολογική και κλινική μελέτη 413 περιπτώσεων |
| Creator |
Pomonis, Eustathios P
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| Abstract |
The clinical course and prognosis of ulcerative colitis was studied in a group of 413 patients. The study lasted for 16 years and follow-up was achieved in 95% of pa-tients. Both sexes were almost equally affected, mainly between the ages of 40-49. Most of the patients lived in cities and had high educational levels. Familial cluster-ing for inflammatory bowel disease was found in 2.7% of the patients. In most of them the disease was confined to the rectosigmoid area or left bowel and was of mild to moderate severity. The disease course included exacerbations -mainly of mild to moderate severity- and remissions. Mortality was absent during first attack and it was generally low at completion of the study. Excluding deaths caused by colorectal cancer, most of deaths were unrelated to the ulcerative colitis itself. Unusual combinations of ulcerative colitis with other diseases including diseases of autoimmune origin, were noted. There were no differences between men and women in the various clinicoepidemiological parameters or in the course of the disease. Surgery was performed in 16.7% of patients whereas surgery at first attack was required in 0.5%. In comparison with the non-operated group, patients who were op-erated on were significantly younger at the time of onset of symptoms and had sig-nificantly more extensive disease. Factors prognostic of severe attacks and colectomy were extensive disease, young age at onset and severe recurrences. Evolution to cancer was observed in 1.45% whereas extraintestinal cancers also appeared in 1.45%. At the completion of the follow-up period, 5.8% of patients were dead, 16% had only one attack, 2.7% ex-perienced continuous symptoms, whereas in 58.8% of them thedisease course in-cluded exacerbations and remissions. On the basis of the outcome of severe attacks, the more favorable short-term prognosis and the low frequency of colorectal cancer appeared on the ground of ul-cerative colitis, it could be argued that ulcerative colitis in Greece runs a rather milder course compared with that of other developed countries in Western Europe and North America.
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| Issue date |
2001-05-01 |
| Date available |
2001-09-06 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Doctoral theses
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Type of Work--Doctoral theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/a/e/6/metadata-dlib-2001pomonis.tkl
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| Views |
220 |
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