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Identifier |
000446229 |
Title |
Synthesis of triple stimuli-responsive diblock and triblock copolymers and their self-assembly behavior |
Alternative Title |
Σύνθεση τριπλά-αποκρίσιμων δισσυσταδικών και τρισυσταδικών συμπολυμερών και η αυτο-οργάνωσή τους |
Author
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Γούναρης Νικολαΐδης, Δημήτριος Ι.
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Thesis advisor
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Βαμβακάκη, Μαρία
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Abstract |
Light-responsive block copolymers have attracted great interest for a variety of
technological and biomedical applications, due to their remote and spatiotemporally
controlled response to the external stimulus. Photo-responsive self-assembled
polymer micelles have been proposed for a variety of applications, such as
nanocarriers to encapsulate hydrophobic molecules within their cores and release
them in response to light irradiation. In this work, multifunctional, stimuli-responsive
triblock copolymers have been synthesized via reversible addition fragmentation
chain transfer (RAFT) polymerization. The well-defined triblock copolymers,
containing a hydrophobic spiropyran methacrylate (SPMA) block, a hydrophilic, pHand temperature-sensitive poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA)
block and a hydrophilic poly(ethylene glycol) (PEG) block, were self-assembled into
spherical core-shell-corona micelles in water. The core of the micelles is sensitive to
changes of the solution temperature and pH as well as to light irradiation, whereas the
shell is temperature- and pH-responsive. In addition, diblock copolymers with a
hydrophobic SPMA block and a hydrophilic PDMAEMA block, which selfassembled into core-shell micelles in water, were synthesized by RAFT
polymerization. The response and the morphology of the copolymer micelles, upon
UV and visible light irradiation, were monitored by UV/vis spectroscopy and field
emission scanning electron microscopy (FESEM). This study focuses on the detailed
investigation and exploitation of the adjustable polymorphism, from the nano to the
micro scale, of the spiropyran-based self-assemblies.
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Language |
English |
Subject |
Stimuli polymers |
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Πολυμερή |
Issue date |
2022-07-28 |
Collection
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School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/5/e/6/metadata-dlib-1646048443-773990-10446.tkl
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Views |
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