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Identifier |
000459853 |
Title |
Insights into the role of nuclear hormone receptor NHR-85 in Caenorhabditis elegans ageing |
Alternative Title |
Στοιχεία για το ρόλο του πυρηνικού υποδοχέα ορμονών NHR-85 στη γήρανση του νηματώδους Caenorhabditis elegans |
Author
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Σπανουδάκης, Εμμανουήλ Ν.
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Thesis advisor
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Ταβερναράκης, Νεκτάριος
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Reviewer
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Γαρίνης, Γεώργιος
Μπαζοπούλου, Δάφνη
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Abstract |
Ageing is defined as the progressive accumulation of damage over time,
leading to the disruption of physiological functions in most living systems. A
major aspect of ageing is associated with energy metabolism, and this
relationship has been extensively investigated. Ageing is known to be
accompanied by a general decrease in energy levels and basal metabolic rate,
as well as alterations in mitochondrial function. Despite reported findings,
though, the association between ageing and energy metabolism remains
largely obscure. In mammals, energy metabolism is regulated by a plethora of
transcription factors, including peroxisome-proliferator-activated receptors
(PPARs), which comprise a major family of nuclear hormone receptors. Of
these, the well-studied PPARα and PPARγ, which participate in key procedures
of lipid metabolism, such as lipogenesis, have been suggested to regulate
inflammation and ageing. In this thesis we aimed to study a putative orthologue
of the least studied isoform PPARδ, named NHR-85, in the nematode model
Caenorhabditis elegans. Our results suggest a direct role for NHR-85 in lifespan
regulation, which is associated with dynamics of neutral lipid content.
Elucidation of the role of NHR-85 in this powerful in vivo model will contribute
to our understanding of the conserved mechanisms of ageing and will direct the
research on its putative mammalian counterpart towards the development of
novel anti-ageing interventions.
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Language |
English |
Subject |
Ageing |
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C. elegans |
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Lipid metabolism |
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NHR-85 |
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NHRs |
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PPARs |
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PPARδ |
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Peroxisomeproliferator-activated receptors |
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Γήρανση |
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Καινοραβδίτης ο κομψός |
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Μεταβολισμός λιπιδίων |
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Πυρηνικοί υποδοχείς ορμονών |
Issue date |
2023-11-24 |
Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/3/2/c/metadata-dlib-1698317274-980480-16421.tkl
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Views |
1182 |
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