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Identifier

000370765

Title

Ανάπτυξη οντολογιών για την μελέτη τροπικών ασθενειών

Alternative Title

Ontology development to study tropical diseases

Author

Τοπάλης, Παντέλης

Thesis advisor

Λούης, Χρήστος

Abstract

Ten years after the publication of the human genome, the functional analysis of human genes is still at an embryonic stage. The use of computers to analyze the increasing volume of the available data accelerated the process and underlined the necessity of bioinformatics into the modern research in the field of molecular biology. At the same time the need for new tools and new ways to semantically organize the available data it became obvious. The use of ontologies is a major step forward towards this direction. Within the frame of this work new ontologies have been created to describe the gross anatomy of mosquitoes, to facilitate detection and monitoring of insecticide resistance often observed in mosquito populations especially in the areas where spraying is the main measure for vector control and finally to describe malaria. Based on these ontologies new tools have been developed to facilitate gene annotation with anatomical terms. Moreover a new database to detect and monitor resistance in an area has been established based on our ontology and it has been adopted as a standard from various international efforts. Finally the malaria ontology created at IMBB resides at the heart of the malaria decision support system created by the innovative vector control consortium.

Language

Greek

Subject

Arthropod vectors

Bioinformatics

Malaria

Αρθρόποδοι φορείς ασθενειών

Βιοπληροφορική

Ελονοσία

Issue date

2012-03-01

Collection