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Identifier

000438209

Title

Εκτίμηση ανταπόκρισης στη χορήγηση χαμηλής δόσης ραδιενεργού ιωδίου σε ασθενείς με διαφοροποιημένο καρκίνο θυρεοειδούς

Alternative Title

Low radioiodine dose in postoperative ablation of residual thyroid tissue in patients with differentiated thyroid carcinoma

Author

Μπουρογιάννη, Όλγα

Thesis advisor

Κουκουράκη, Σοφία

Reviewer

Ξεκούκη, Παρασκευή
Προκοπάκης, Εμμανουήλ

Abstract

Aim: Radioactive iodine-131 (RAI) has been widely reported in the treatment of patients with differentiated thyroid cancer (DTC) since 1960’s. Selecting an optimal dose of radioiodine for successful ablation is a continuous challenge in low risk patients. The aim of this study was to compare the success rate of low and high activities of I-131 for postoperative remnant ablation using 60mCi or 100mCi 131-I in papillary thyroid cancer patients and to assess clinical outcome 36-months after RAI therapy. Patients- Methods: In order to achieve these targets a retrospective study took place in Therapy Unit of Nuclear Medicine Department in University Hospital of Heraklion. The sample of the study was consisted of 229 low risk patients (52 males, 177 females) who have undergone thyroidectomy, with histological diagnosis of well differentiated thyroid cancer. 118 patients received a low dose (60mCi) and 111 patients received a high dose (100mCi) of 131-Ι. The response to remnant ablation was defined as successful or unsuccessful according to post-therapy ultrasonography of the neck, diagnostic Whole Body Scan, serum thyroglobulin (Tg), and anti-Tg. The follow up completed 36 months after RAI therapy and recurrence rates were assessed. Results: Successful ablation was 95,7% in the low dose and 97,2 % in the high dose group (no statistically significant difference in ablation rates). The recurrence rates were 0,8% in the low dose group and 2,7% in the high dose group. The differences were not statistically significant between the two groups. Further evaluations within the groups based on demographical factors (age, sex) and the interval between the RAI therapy and referral to the assessment of the ablation efficacy did not reveal any statistically significant associations to the successful ablation rate and the recurrence rate. Conclusions: Our findings suggest that remnant thyroid tissue in patients with low-risk, well-differentiated thyroid cancer can be ablated with low radioiodine dose. The success and recurrence rate is not different from that obtained with high dose.

Language

Greek, English

Subject

Ablation success rate

Thyroid cancer

radioactive iodine-131 therapy

recurrence rate

Επιτυχής θεραπεία εκρίζωσης

Θεραπεία με ραδιενεργό ιώδιο

Issue date

2021-03-29

Collection